The publication, Working with Architectonic DNA, explores the phenomenon of designing complex architectural projects that require continuous modification including expansion and contraction. The departure point is Schiphol Airport in the Netherlands - an airport landscape of train lines, corporate architecture, highways, retail shops, etc. - a project that represents a space in constant flux as air travel patterns change depending on the world's economic state. Dutch architect, Jan Benthem, who has made numerous designs for Amsterdam Schiphol Airport since the 1960s, describes these projects as 'working with an architectonic DNA where the projects have to be finished in any stage of the design and construction'. Departing from Jan Benthem's statement the publication reflects upon the idea of designing with an architectonic DNA and explores links with various disciplines. Texts and interviews by architects, urban planners, philosophers, interior designers and researchers investigate this architectural phenomenon from their professional points of view. The questions are: What is the essence, the conceptual basis of an 'architectonic DNA'? Is it possible to design with a so-called architectonic DNA? What are the relevant tools and methods to achieve this design?